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Year : 2017  |  Volume : 3  |  Issue : 1  |  Page : 1-13

The role of hormesis in the functional performance and protection of neural systems

1 Department of Environmental Health Sciences, School of Public Health and Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
2 Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Viale Andrea Doria, Catania, Italy
3 Department of Neurology and Biochemistry, Georgetown University Medical Center, Washington, DC 20057, USA

Correspondence Address:
Prof. Edward J Calabrese
School of Public Health and Health Sciences, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2394-8108.203257

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This paper addresses how hormesis, a biphasic dose response, can protect and affect performance of neural systems. Particular attention is directed to the potential role of hormesis in mitigating age-related neurodegenerative diseases, genetically based neurological diseases, as well as stroke, traumatic brain injury, seizure, and stress-related conditions. The hormetic dose response is of particular significance since it mediates the magnitude and range of neuroprotective processes. Consideration of hormetic dose-response concepts can also enhance the quality of study designs, including sample size/statistical power strategies, selection of treatment groups, dose spacing, and temporal/repeat measures' features.

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