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Year : 2019  |  Volume : 5  |  Issue : 3  |  Page : 130-133

Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine

1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, FL, USA
2 Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan

Correspondence Address:
Dr. Yun Wang
National Health Research Institutes, Zhunan, Miaoli County
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bc.bc_40_19

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A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the immunorejection of human-induced pluripotent stem cells (iPSCs) through co-grating nanoparticles-containing cyclosporine A (NanoCsA) in hemiparkinsonian rats. The study supported the notion that NanoCsA allows for long-lasting CsA discharge and limits immunorejection of human iPSC xenograft in a 6-hydroxydopamine Parkinson's disease rat model.

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