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Year : 2021  |  Volume : 7  |  Issue : 1  |  Page : 29-32

The unsolved mystery of hippocampal cholinergic neurostimulating peptide: A potent cholinergic regulator

1 Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA
2 Department of Neurology, Nagoya City University, Nagoya, Japan

Correspondence Address:
Noriyuki Matsukawa
Department of Neurology, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Aichi 467-8601
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bc.bc_14_21

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This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observed to attenuate behavioral deficits and decrease microglia activation and proinflammatory cytokines, illustrating its ability to mitigate the secondary cell death following stroke. Similar anti-neuroinflammation treatments, such as transplantation of mesenchymal stem cells and mitochondrial transfers, are briefly discussed to provide further support that sequestration of inflammation stands as a robust therapeutic target for stroke.

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