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Year : 2022  |  Volume : 8  |  Issue : 4  |  Page : 225-227

Isolated cerebellar infarction in a case of JAK 2 mutation-negative polycythemia vera: A case report

Department of Neurosurgery, National Neurosciences Centre, Kolkata, West Bengal, India

Correspondence Address:
Prasad Krishnan
Department of Neurosurgery, National Neurosciences Centre, 2nd Floor, Peerless Hospital Campus, 360, Pancha Sayar, Garia, Kolkata - 700 094, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bc.bc_37_22

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Polycythemia vera is a myeloproliferative disorder caused by clonal expansion of erythroid precursors in the bone marrow commonly due to a mutation in the Janus kinase 2 (JAK2) gene located in the short arm of chromosome 9. Hyperviscosity of blood due to high hematocrit causes a low flow state that may predispose to infarct. These commonly occur in the supratentorial compartment. The case of a 46-year-old man who had an isolated cerebellar infarct with high hematocrit and hemoglobin levels and low serum erythropoietin levels is described. Further investigations eventually led to the unmasking of a JAK2 mutation-negative polycythemia vera.

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