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Figure 1: Effect of mild hypothermia on microRNA expression after cerebral ischemia. middle cerebral artery occlusion animals were subjected to transient cerebral ischemia for 2 h, with 3 h of normothermia or hypothermia treatment from the induction of cerebral ischemia and were sacrificed at 24 h after cerebral ischemia. (a) The quality of total RNA extracted from the cortex was confirmed by formaldehyde gel electrophoresis. (b) Hierarchical clustering analysis of sham-operated, cerebral ischemia treated with mild hypothermia or normothermia groups at 24 h after ischemia. Heatmap coloring indicates relative signal intensities related to microRNA expression levels. The blue box represents downregulation, yellow represents upregulation, and black represents no change. n = 3 rats per group. 37°C, normothermia; 33°C, mild hypothermia

Figure 1: Effect of mild hypothermia on microRNA expression after cerebral ischemia. middle cerebral artery occlusion animals were subjected to transient cerebral ischemia for 2 h, with 3 h of normothermia or hypothermia treatment from the induction of cerebral ischemia and were sacrificed at 24 h after cerebral ischemia. (a) The quality of total RNA extracted from the cortex was confirmed by formaldehyde gel electrophoresis. (b) Hierarchical clustering analysis of sham-operated, cerebral ischemia treated with mild hypothermia or normothermia groups at 24 h after ischemia. Heatmap coloring indicates relative signal intensities related to microRNA expression levels. The blue box represents downregulation, yellow represents upregulation, and black represents no change. <i>n</i> = 3 rats per group. 37°C, normothermia; 33°C, mild hypothermia